For more than 100 years Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach it provides cutting-edge coverage of automation informatics molecular diagnostics proteomics laboratory management and quality control emphasizing new testing methodologies throughout.
Key Features
Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests.
Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement.
Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management.
Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams.
Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection.
Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author Information
Richard A. McPherson, MD, MSc, Professor of Pathology, Emeritus, Virginia Commonwealth University, Richmond, Virginia and Matthew R. Pincus, MD, PhD, Professor, Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, New York; Chief, Department of Pathology and Laboratory Medicine, New York Harbor VA Medical Center, New York, New York
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Part 1: The Clinical Laboratory
1. General Concepts and Administrative Issues 2. Optimizing Laboratory Workflow and Performance 3. Preanalysis 4. Analysis: Principles of Instrumentation 5. Mass Spectrometry and Applications 6. Analysis: Clinical Laboratory Automation 7. Point-of-Care Testing and Physician Office Laboratories 8. Postanalysis: Medical Decision Making 9. Interpreting Laboratory Results 10. Laboratory Statistics 11. Quality Control 12. Clinical Laboratory Informatics 13. Financial Management 14. Ethics in Laboratory Medicine
Part 2: Clinical Chemistry
15. Evaluation of Renal Function, Water , Electrolytes and Acid-Base Function 16. Biochemical Markers of Bone Metabolism 17. Carbohydrates 18. Lipids and Dyslipoproteinemia 19. Cardiac Injury, Atherosclerosis, and Thrombotic Disease 20. Specific Proteins 21. Clinical Enzymology 22. Evaluation of Liver Function 23. Laboratory Diagnosis of Gastrointestinal and Pancreatic Disorders 24. Toxicology and Therapeutic Drug Monitoring 25. Evaluation of Endocrine Function 26. Reproductive Function and Pregnancy 27. Vitamins and Trace Elements 28. Chemical Basis for Analyte Assays and Common Interferences
Part 3: Urine and Other Body Fluids
29. Basic Examination of Urine 30. Cerebrospinal, Synovial, Serous Body Fluids, and Alternative Specimens
Part 4: Hematology and Transfusion Medicine
31. Basic Examination of Blood and Bone Marrow 32. Hematopoiesis 33. Erythrocytic Disorders 34. Leukocytic Disorders 35. The Flow Cytometric Evaluation for Hematopoietic Neoplasia 36. Immunohematology 37. Transfusion Medicine 38. Hemapheresis 39. Tissue Banking and Progenitor Cells
Part 5: Hemostasis and Thrombosis
40. Coagulation and Fibrinolysis 41. Platelet Disorders and Von Willebrand Disease 42. Laboratory Approach to Thrombotic Risk 43. Antithrombotic Therapy
Part 6: Immunology and Immunopathology
44. Overview of the Immune System and Immunologic Disorders 45. Immunoassays and Immunochemistry 46. Laboratory Evaluation of the Cellular Immune System 47. Laboratory Evaluation of Immunoglobulin Function and Humoral Immunity 48. Mediators of Inflammation: Complement 49. Mediators of Inflammation: Cytokines and Adhesion Molecules 50. Human Leukocyte Antigen: The Major Histocompatibility Complex of Man 51. The Major Histocompatibility Complex and Disease 52. Immunodeficiency Disorders 53. Clinical and Laboratory Evaluation of Systemic Autoimmune Rheumatic Diseases 54. Vasculitis 55. Organ-Specific Autoimmune Diseases 56. Allergic Diseases
Part 7: Medical Microbiology
57. Medical Bacteriology 58. In Vitro Testing of Antimicrobial Agents 59. Mycobacteria 60. Mycotic Diseases 61. Spirochete Infections 62. Chlamydial and Mycoplasmal Infections 63. Rickettsiae and Other Related Intracellular Bacteria 64. Viral Infections 65. Medical Parasitology 66. Specimen Collection and Handling for Diagnosis of Infectious Diseases
Part 8: Molecular Pathology
67. Introduction to Molecular Pathology 68. Molecular Diagnostics: Basic Principles and Techniques 69. Polymerase Chain Reaction and Other Nucleic Acid Amplification Technology 70. Hybridization Array Technologies 71. Applications of Cytogenetics in Modern Pathology 72. Molecular Diagnosis of Genetic Diseases 73. Molecular Genetics of Neuro-Psychiatric Disorders: Current Research and Perspectives 74. Identity Testing: Use of DNA Analysis in Parentage, Forensic, and Missing Persons Testing 75. Pharmacogenomics and Personalized Medicine
Part 9: Clinical Pathology of Cancer
76. Diagnosis and Management of Cancer Using Serologic and Other Body Fluid Markers 77. Oncoproteins and Early Tumor Detection 78. Molecular Diagnosis of Hematopoietic Neoplasms 79. Molecular Genetic Pathology of Solid Tumors 80. High-Throughput Genomic and Proteomic Technologies in the Post-Genomic Era
Appendices Physiologic Solutions, Buffers, Acid-Base Indicators, Standard Reference Materials, and Temperature Conversions Desirable Weights, Body Surface Area, and Body Mass Index Approximations of Total Blood Volume Periodic Table of Elements SI Units Common Chimeric Genes Identified in Human Malignancies Disease/Organ Panels
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