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Offering comprehensive coverage of the clinical, physical, and technical aspects of radiation treatment planning, Khan’s Treatment Planning in Radiation Oncology, Fifth Edition, provides a team approach to this complex field. Drs. Paul W. Sperduto and John P. Gibbons are joined by expert contributing authors who focus on the application of physical and clinical concepts to solve treatment planning problems—helping you provide effective, state-of-the-art care for cancer patients. This unique, well-regarded text has been updated throughout to reflect the most current practices in today’s radiation oncology treatment. 

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SECTION I
Treatment Planning: Safety and Biological
Principles 1
CHAPTER 1 Patient Safety 2
Lukasz M. Mazur, Lawrence B. Marks, Shiva Das,
Ross McGurk, Karthik Adapa, Alison N. Amos,
Deen Gu, Bret Shultz, and Bhisham Chera
CHAPTER 2 Normal Tissue Tolerance 26
Dominic H. Moon and Robert D. Timmerman
CHAPTER 3 Fractionation: Radiobiologic Principles and
Clinical Practice 41
Colin Orton
CHAPTER 4 Immunologic Principles of Treatment Planning:
Radiation as In Situ Vaccine and Dose
Fractionation in the Immunotherapy Era 56
Andrew Brandmaier
SECTION II
Treatment Planning: Site-Specific
Cancers 67
CHAPTER 5 Cancers of the Central Nervous System 68
Vinai Gondi, Paul W. Sperduto, and
Minesh P. Mehta
CHAPTER 6 Cancers of the Head and Neck 87
Yolanda I. Garces, Charles Mayo, Christopher Beltran,
and Robert L. Foote
CHAPTER 7 Cancers of the Thorax/Lung 108
Gregory M.M. Videtic, Rupesh Kotecha,
Neil M. Woody, and Kevin L. Stephans
CHAPTER 8 Breast Cancer 134
Susan G.R. McDuff, Colin E. Champ, Sua Yoo, and
Rachel C. Blitzblau
CHAPTER 9 Cancers of the Gastrointestinal Tract 155
David Carpenter, Jordan Torok, Christopher G. Willett,
Fang-Fang Yin, and Brian G. Czito
CHAPTER 10 Cancer of the Genitourinary Tract: Prostate,
Bladder, and Testicular Cancer 189
Stephanie M. Yoon, Andrew S. Lim, and Albert Chang
CHAPTER 11 Gynecologic Malignancies 240
Aaron B. Simon, Daniel R. Simpson, Loren K. Mell,
Dominique Rash, Jyoti Mayadev, Arno J. Mundt, and
Catheryn M. Yashar
CHAPTER 12 The L ymphomas 269
John P. Plastaras, Stefan Both, and Ima Paydar
CHAPTER 13 Cancers of the Skin, Including Mycosis
Fungoides 284
Zhe (Jay) Chen, James C. L. Chow, Alexander Sun,
Himanshu Nagar, Kenneth R. Stevens Jr., and
Jonathan P. S. Knisely
CHAPTER 14 Pediatric Malignancies 309
Myrsini Ioakeim–Ioannidou, Shannon M. MacDonald,
and Nancy J. Tarbell
CHAPTER 15 Soft Tissue and Bone Sarcoma 330
Kilian E. Salerno, Yen-Lin Chen, Thomas F. DeLaney,
and Elizabeth H. Baldini
SECTION III
Treatment Planning: Physics and Dosimetric
Principles 365
CHAPTER 16 Introduction: Process, Equipment, and
Personnel 366
Faiz M. Khan and John P. Gibbons
CHAPTER 17 Image-Guided Radiation Therapy 374
Guang Li, Gig S. Mageras, Lei Dong, and
Radhe Mohan
CHAPTER 18 Deformable Image Registration 404
Raj Varadhan
CHAPTER 19 P atient Simulation 420
Dimitris N. Mihailidis and Niko Papanikolaou
CHAPTER 20 Treatment Planning Algorithms: Photon Dose
Calculations 437
John P. Gibbons
CHAPTER 21 Treatment Planning Algorithms:
Brachytherapy 452
Kenneth J. Weeks
CHAPTER 22 Treatment Planning Algorithms: Electron
Beams 467
Kenneth R. Hogstrom, Garrett M. Pitcher,
Robert L. Carver, and John A. Antolak
ContentsCHAPTER 23 Treatment Planning Algorithms: Proton
Therapy 496
Hanne M. Kooy, Benjamin M. Clasie,
and Nicolas Depauw
CHAPTER 24 Commissioning and Quality Assurance 507
Francisco J. Reynoso and James A. Kavanaugh
CHAPTER 25 Intensity-Modulated Radiation Therapy:
Photons 528
Jan Unkelbach
CHAPTER 26 Patient and Organ Movement 560
Paul J. Keall and James M. Balter
CHAPTER 27 Linac Radiosurgery: System Requirements,
Procedures, and Testing 570
Frank J. Bova, William A. Friedman,
and Jonathan G. Li
CHAPTER 28 Stereotactic Ablative Radiotherapy 595
Mu-Han Lin, Andrew Godley, and
Robert D. Timmerman
CHAPTER 29 Low Dose-Rate Brachytherapy 613
Yun Yang and Mark J. Rivard
CHAPTER 30 High-Dose-Rate Brachytherapy Treatment
Planning 629
Bruce R. Thomadsen, Jessica Miller, Poonam Yadav,
and Susan Richardson
CHAPTER 31 Electron Beam Treatment Planning 665
John A. Antolak
CHAPTER 32 Proton Beam Therapy 690
Hanne M. Kooy, Judith Adams,
and Nicolas Depauw
CHAPTER 33 Treatment Plan Evaluation 704
Ellen D. Yorke, Andrew Jackson,
and Gerald J. Kutcher
CHAPTER 34 Knowledge-Based T reatment Planning 722
Todd R. McNutt, John P. Gibbons, and Binbin Wu
Index 735



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