This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of normal histology of every organ system, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Normal Histology is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Covers all areas of normal histology, including introductory chapters on electron microscopy, immunofluorescence, immunohistochemistry and histochemistry, the cell, and the basic organization of tissues Includes important updates throughout, covering not only traditional normal histology but also its morphologic spectrum (variant normal histology), as well as recent advances in immunohistochemistry that expand the spectrum of antigen expression in normal tissues Contains new images in over 75% of the chapters, including images of the most common abnormal findings in each organ system, helping provide direct contrast with adjacent normal histology (i.e., what is normal and what is not) Provides the at-a-glance information necessary for diagnosis or adequacy evaluation at the time of procedure, using a concise, synoptic writing style Features more than 2,000 print and online images, including carefully annotated photomicrographs, gross images, electron micrographs, and full-color medical illustrations to help practicing and in-training pathologists reach a confident diagnosis Employs consistently templated chapters, bulleted content, key facts, a variety of test data tables, annotated images, and an extensive index for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
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SECTION 1: INTRODUCTION TO NORMAL
HISTOLOGY AND BASIC HISTOLOGICAL
TECHNIQUES
4 Introduction to the Cell
Jerome B. Taxy, MD and Anthony Chang, MD
12 Introduction to Histology
Laura W. Lamps, MD and Matthew R. Lindberg, MD
22 General Histologic Artifacts
Matthew R. Lindberg, MD
24 Histochemistry (Special Stains)
Matthew R. Lindberg, MD and Laura W. Lamps, MD
28 Immunohistochemistry of Normal Tissues
Matthew R. Lindberg, MD and Laura W. Lamps, MD
32 Immunofluorescence
Anthony Chang, MD
36 Electron Microscopy
Anthony Chang, MD, Peter Pytel, MD, and Jerome B. Taxy, MD
SECTION 2: INTEGUMENT
42 Epidermis (Including Keratinocytes and
Melanocytes)
David Cassarino, MD, PhD and Aaron Auerbach, MD, MPH
46 Dermis
David Cassarino, MD, PhD
50 Adnexal Structures
David Cassarino, MD, PhD
54 Nail
David Cassarino, MD, PhD and Aaron Auerbach, MD, MPH
SECTION 3: MUSCULOSKELETAL SYSTEM
58 Bone and Cartilage
Matthew R. Lindberg, MD
66 Synovial Membrane
Matthew R. Lindberg, MD
68 Connective Tissue
Matthew R. Lindberg, MD
72 Adipose Tissue
Cyril Fisher, MD, DSc, FRCPath
76 Skeletal Muscle
Matthew R. Lindberg, MD and Cyril Fisher, MD, DSc, FRCPath
SECTION 4: CIRCULATORY SYSTEM
84 Heart
Dylan V. Miller, MD
88 Cardiac Valves
Dylan V. Miller, MD
90 Cardiac Conduction System
Dylan V. Miller, MD
94 Arteries
Dylan V. Miller, MD
98 Capillaries, Veins, and Lymphatics
Dylan V. Miller, MD
SECTION 5: NERVOUS SYSTEM
104 Peripheral Nervous System
Alexandros D. Polydorides, MD, PhD
108 Central Nervous System
Alexandros D. Polydorides, MD, PhD
112 Meninges
Alexandros D. Polydorides, MD, PhD
114 Choroid Plexus
Alexandros D. Polydorides, MD, PhD
SECTION 6: HEMATOPOIETIC AND
IMMUNE SYSTEMS
118 Overview of Immune System
Jeremy C. Wallentine, MD
122 Lymph Nodes
Jeremy C. Wallentine, MD
126 Spleen
Jeremy C. Wallentine, MD
130 Bone Marrow
Kathryn Foucar, MD
138 Peripheral Blood
Kathryn Foucar, MD
142 Thymus
Matthew R. Lindberg, MD
SECTION 7: HEAD AND NECK
148 Eye and Ocular Adnexa
Charles Matthew Quick, MD
158 Oral Mucosae
Brenda L. Nelson, DDS, MS
160 Gingivae
Brenda L. Nelson, DDS, MS
162 Teeth
Brenda L. Nelson, DDS, MS
166 Tongue
Jonathan B. McHugh, MD
170 Tonsils/Adenoids
Jonathan B. McHugh, MD
174 Ear
Jonathan B. McHugh, MD
178 Nose and Paranasal Sinuses
Jonathan B. McHugh, MD
182 Minor Salivary Glands
Brenda L. Nelson, DDS, MS
184 Major Salivary Glands
Jonathan B. McHugh, MD
188 Pharynx
Jonathan B. McHugh, MD
190 Larynx
Jonathan B. McHugh, MD
SECTION 8: RESPIRATORY SYSTEM
196 Trachea
Matthew R. Lindberg, MD
198 Lung
Matthew R. Lindberg, MD
206 Pleura and Pericardium
Matthew R. Lindberg, MD
SECTION 9: BREAST
210 Breast
David G. Hicks, MD
SECTION 10: TUBULAR GUT AND
PERITONEUM
218 Esophagus
Matthew R. Lindberg, MD
224 Stomach
Laura W. Lamps, MD and Matthew R. Lindberg, MD
232 Small Intestine
Laura W. Lamps, MD and Matthew R. Lindberg, MD
238 Large Intestine
Matthew R. Lindberg, MD
246 Appendix
Matthew R. Lindberg, MD
252 Anus and Anal Canal
Laura W. Lamps, MD
256 Peritoneum
Matthew R. Lindberg, MD
SECTION 11: HEPATOBILIARY TRACT
AND PANCREAS
260 Liver
Laura W. Lamps, MD
268 Gallbladder
Laura W. Lamps, MD
272 Extrahepatic Biliary Tract
Laura W. Lamps, MD
276 Vaterian System
Laura W. Lamps, MD
278 Pancreas
Laura W. Lamps, MD
SECTION 12: GENITOURINARY AND MALE
GENITAL TRACT
286 Kidney
Anthony Chang, MD
296 Ureter and Renal Pelvis
Jesse K. McKenney, MD
300 Bladder
Roni Michelle Cox, MD
306 Urethra
Jesse K. McKenney, MD
312 Prostate: Regional Anatomy With Histologic
Correlates
Jesse K. McKenney, MD
322 Prostate: Benign Glandular and Stromal Histology
Jesse K. McKenney, MD
332 Penis
Roni Michelle Cox, MD
336 Testis and Associated Excretory Ducts
Roni Michelle Cox, MD and Matthew R. Lindberg, MD
SECTION 13: FEMALE GENITAL TRACT
346 Vulva
Jesse K. McKenney, MD and Charles Matthew Quick, MD
350 Vagina
Jesse K. McKenney, MD and Charles Matthew Quick, MD
354 Uterus
Charles Matthew Quick, MD
368 Fallopian Tube
Charles Matthew Quick, MD
374 Ovary
Charles Matthew Quick, MD
384 Placenta
Charles Matthew Quick, MD
SECTION 14: ENDOCRINE
392 Adrenal Gland
Roni Michelle Cox, MD and Matthew R. Lindberg, MD
398 Paraganglia
Jesse K. McKenney, MD
400 Thyroid
Jonathan B. McHugh, MD
404 Parathyroid
Jonathan B. McHugh, MD
408 Pineal Gland
Alexandros D. Polydorides, MD, PhD
410 Pituitary
Alexandros D. Polydorides, MD, PhD
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