Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. Reflects the latest advances in the field, including current insights on immune system function, both basic and translational. Contains 50 chapters written by leaders in all subfields of immunology. Provides extensive coverage of the molecular biology that explains the dynamics underlying immune disorders and their treatment. Includes 10 entirely new chapters covering invertebrate and plant immunity, eosinophils, innate lymphoid cells, gamma/delta T cells, NKT and MAIT cells, immunometabolism, maternal-fetal immunology and more. Contains abundant full-color illustrations and tables that provide essential information at a glance. Features annual updates from the authors to the VST version, keeping you current with changes in this dynamic field from the experts.
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C ontents Contributors vii Foreword xiii Preface xvii Section I. Introduction to Immunology 1 Overview of the Immune System ............... 1 Martin F. Flajnik, Steven M. Holland, Nevil J. Singh 2 History of Immunology ....................... 29 Edward J. Moticka Section II. Evolution of the Immune System 3 The Insect Immune System ................... 52 Sara Cherry, Nicolas Buchon 4 Evolution of the Vertebrate and Lower Deuterostome Immune System ................ 79 Martin F. Flajnik 5 The Plant Immune System ................... 134 Roger W. Innes Section III. Cellular Pathways and Processes in Immunity 6 Immunometabolism ........................ 161 Jonathan D. Powell, Chirag H. Patel, Im- Hong Sun 7 Regulated Cell Death in the Immune System .. 204 Douglas R. Green, Sebastian Ruehl 8 Lymphoid Tissues and Organs ............... 228 Martin F. Flajnik, Nancy H. Ruddle 9 Type I Cytokines, Interferons, and Their Receptors ................................. 258 Achsah D. Keegan, Warren J. Leonard 10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors ............................. 308 Carl F. Ware, Nancy H. Ruddle 11 Chemokines and Chemokine Receptors ....... 344 Philip M. Murphy Section IV. Innate Immunity 12 Pattern Recognition Receptors and the IL- 1 Family ............................. 386 Rajendra Karki, Thirumala- Devi Kanneganti 13 The Complement System .................... 416 Erin E. West, Claudia Kemper 14 Neutrophils ............................... 455 Andres Hidalgo, Mariana J. Kaplan 15 Macrophages .............................. 469 Gwendalyn J. Randolph 16 Mast Cells and Basophils ................... 487 Mindy Tsai, Stephen J. Galli 17 Eosinophils ................................ 519 Elizabeth A. Jacobsen, Hirohito Kita 18 The Biology of Natural Killer Cells and Innate Lymphoid Cells ............................ 537 Vincent Peng, Marco Colonna Section V. Adaptive Immunity 19 The Major Histocompatibility Complex ....... 573 David H. Margulies, Kannan Natarajan, Jamie Rossjohn, James McCluskey 20 Classical Antigen Processing and Presentation ............................... 622 Jonathan W. Yewdell, Paul Roche, Laurence C. Eisenlohr 21 Immunoglobulins: Structure and Function .................................. 644 Mohamed Khass, David Wald, Neil S. Greenspan, Harry W. Schroeder, Jr 22 Immunoglobulins: Molecular Genetics ....... 671 Sebastian D. Fugmann 23 T Cell Antigen Receptors and Antigen Recognition ............................... 702 Mark M. Davis, Yueh- Hsiu Chien 24 Antigen Receptor Signaling ................. 734 Nevil J. Singh, Gideon Wolf 25 B Cell Development in Mice ................. 774 Nicole Baumgarth 26 B Cell Responses .......................... 798 Claude- Agnès Reynaud, Jean- Claude Weill 27 T Cell Development in the Thymus ........... 823 Avinash Bhandoola, Remy Bosselut, Yousuke Takahama 28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity ............... 856 John J. O’Shea, Marion Pepper, Marc K. Jenkins, Danielle A. Chisolm 29 Regulatory T Cells .......................... 874 Ethan M. Shevach 30 CD8+ T Cell Memory ........................ 924 Francis R. Carbone, Thomas Gebhardt 31 Cytotoxic Effector Functions ................. 944 Morgan Huse Section VI. Integrative Immunology 32 Immunologic Tolerance ..................... 971 Colin C. Anderson, Troy A. Baldwin, Peter A. Bretscher 33 Fc Receptors and Their Role in Immune Regulation and Inflammation ............... 1008 Jeffrey V. Ravetch, Aaron Gupta, Falk Nimmerjahn 34 Dendritic cells ............................ 1034 Roxane Tussiwand, Pierre Guermonprez, Simon Yona 35 Gamma Delta T Cells ...................... 1054 Adrian C. Hayday 36 CD1- Restricted T Cells ..................... 1102 Pankaj Sharma, Florian Winau 37 Mucosal- Associated Invariant T Cells and Other MR1- Reactive T Cells ................ 1137 Sidonia B. G. Eckle, Wael Awad, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett 38 The Mucosal Immune System .............. 1178 Yasmine Belkaid, Brian L. Kelsall, Warren Strober 39 Introduction to Neuroimmunology ........... 1212 Andrea Francesca Salvador, Jonathan Kipnis 40 Vaccines ................................. 1231 Bali Pulendran 41 Maternal- Fetal Immunology ................ 1283 Gabrielle Rizzuto, Adrian Erlebacher Section VII. Immune Responses to Pathogens 42 Response to Parasites ..................... 1325 David Sacks, Marion Pepper, Mary F. Fontana, P’ng Loke 43 Immune Responses to Bacteria ............. 1355 S. Celeste Morley, Moon H. Nahm 44 Response to Viruses ....................... 1399 Hildegund C. J. Ertl 45 Immunology of HIV Infection ............... 1445 Gaurav D. Gaiha, Douglas S. Kwon Section VIII. Immunological Disease States and Immunodeficiency 46 Autoimmunity and Autoimmune Diseases .... 1465 Gustaf Christoffersson, Ken T. Coppieters, Matthias von Herrath, Dirk Homann 47 Immunologic Mechanisms of Allergic Disorders ................................ 1515 Stéphanie Lejeune, Kari C. Nadeau, David W. Scott, Joshua D. Milner 48 Transplantation Immunology ............... 1549 Megan Sykes, Anita S. Chong, Markus Y. Mapara 49 Cancer Immunology and Immunotherapy ..... 1589 Thomas F. Gajewski, Justin Kline 50 Inborn Errors of Immunity .................. 1619 Isabelle Meyts, Jean- Laurent Casanova, Luigi D. Notarangelo Index 1649
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