Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system.
Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study
-도서목차-
1. Mitochondria in functions of nervous system 2. Mitochondrial calcium homeostasis in synaptic functions 3. Mitochondrial regulation of neuronal plasticity 4. Communication between mitochondria and other organelles 5. Axoplasmic mitochondrial transport: From Molecules to Mechanisms 6. Yeast as a model for studying human neurodegenerative disorders 7. Sex differences in mitochondrial metabolism 8. Mitochondrial oxidative stress and neurodegeneration 9. Mitochondrial metabolism in neurological disorders 10. Altered mitochondrial signalling in neurodegenerative conditions 11. Mitochondrial DNA, base excision repair and neurodegeneration 12. microRNAs regulating mitochondrial functions in brain 13. Mitochondrial Chaperones in Neurodegenerative Disorders 14. Proteomic profiling of mitochondria in neurodegenerative conditions 15. Association of mitochondrial genetic variants with neurological disorders 16. Mitochondrial dynamics in diseases of nervous system 17. Mitochondrial thiol dioxygenases in diseases of the nervous system 18. Mitophagy in Neurodegenerative Diseases 19. Mitochondria and neuroinflammation 20. Mitochondrial functions in Alzheimer’s Disease 21. Mitochondria in Amyotrophic lateral sclerosis 22. Pathways involved in mitochondrial dysfunctions in Huntington’s Disease 23. Mitochondrial cascades in Parkinson’s Disease 24. Mitochondrial dysfunctions in Psychiatric Disorders 25. Mitochondria in Brain Injury 26. Mitochondrial epigenetics in neurodegeneration 27. Transmitochondrial Cybrids: A cellular model to study mutant mitochondria 28. Targeting mitochondria in neurodegenerative disorders 29. Mitochondrial modulators in neuroprotection 30. Polyphenols and mitochondria in neurodegneration 31. Transplantation of mitochondria in neurodegenerative disorders
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