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의학서적전문 "성보의학서적"의 신간의학도서입니다.

Early Detection of Alzheimer’s Disease: Biological and Technological Advances aims to introduce to a wide audience the high global priority problem of detecting AD prior to dementia onset. According to the Alzheimer’s Association, 5.8 million Americans are living with Alzheimer’s and care costs will cost the nation approximately $290 billion (2019 Alzheimer’s Disease Facts and Figures). With the failure of recent AD drug trials, many hypothesize that by the time symptoms appear, it is too late to be treated. Early detection can offer benefits such as more choice of medications, ability to participate in clinical trials, more time for family and for care planning. This book outlines potential solutions to the above problem using opportunities arising from the technology revolution, advances in neuroscience, and molecular biology. Most importantly, it discusses a paradigm shift from a reactive to a proactive diagnostic approach, aiming to detect disease before occurrence of symptoms. Topics covered include the use of sensing technologies (e.g. smartphones, smartwatches, Internet of Things) to detect early disease-related changes, the application of data science (machine learning/AI) to extract otherwise invisible disease features from these datasets and the potential to personalize diagnosis based on tracking changes in individual behaviours. Advances in blood-based biomarkers, brain imaging, and the potential for early diagnosis to aid interventions (lifestyle, dietary, pharmacological) to delay future development of dementia are also discussed.

Outlines the importance of early diagnosis of Alzheimer’s Disease
Helps readers understand the limitations of current clinical approaches and the need for a paradigmatic shift in diagnostic practice
Discusses the potential role of technology in clinical practice using machine learning and artificial intelligence and the potential to personize diagnosis and treatmen

-도서목차-


1. Foreword

2. Introduction

Opportunities and challenges provided by the tech revolution
The need for futureproofing and the importance of mitigating against the risk of obsolescence

3. Early Alzheimer’s disease

Pathology
The syndrome of mild cognitive impairment
Management

4. The need for early diagnosis

Clinical, societal and health economic drivers
The aging population
Global inequalities in access to diagnostics
Scientific drivers
The need to integrate with basic neuroscience
Need for functionally relevant outcome measures

5. An overview of current diagnostic strategies

Neuroimaging
Cognitive testing
Clinical evaluation

6. Novel approaches to diagnosis

Opportunities arising from the tech revolution
App-based testing
Machine learning/AI
Big data
Personalised diagnostics
Advances in imaging
Advances in biomarkers, incl blood-based methods
Advances in cognitive testing

7. Challenges for the new approach

Ethical issues about early diagnosis in the absence of a cure
Privacy

8. An eye to the future

Beyond diagnosis: how to use such approaches for intervention
Clinical trials
the emerging landscape of disease-modifying drugs
novel trial outcome measures
Non-pharmacological interventions
Next generation approaches

기타 의학도서에 관련된 문의사항은 고객센터(02-854-2738) 또는 저희 성보의학서적 홈페이지내 도서문의 게시판에 문의바랍니다.
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