This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Key Features
Provides a comprehensive source for key pathologies and clinical features of more than 265 kidney diseases Features two dozen new chapters on a variety of timely topics, including COVID-19 nephropathies, xenografts, artificial intelligence (AI), digital pathology analysis, harmonized nephropathology terminology, newly identified types of amyloidosis, common artifacts and pitfalls on kidney biopsy, vaccination-associated renal disease, crystal nephropathies, and much more Includes updates from the International Kidney and Monoclonal Gammopathy (IKMG) research group, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-related disease, Banff Foundation for Allograft Pathology, and others Details updated genetic causes of nephrotic syndromes and antinephrin antibodies in podocytopathies—by the investigator who discovered it Discusses the newly identified variant IgG nephropathy and novel membranous autoantigens Contains chapters on techniques, including immunofluorescence on paraffin sections, C4d staining, and polyomavirus detection in tissue Contains more than 4,300 print and online images, including high-resolution photographs and histologic images, full-color medical illustrations, radiologic images, and more Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Shares the expertise of internationally recognized authors who provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
Author Information
By Robert B. Colvin, MD, Benjamin Castleman Distinguished Professor of Pathology, Department of Pathology, Harvard Medical School, Pathologist-in-Chief, Emeritus, Massachusetts General Hospital, Boston, Massachusetts; Anthony Chang, MD, Professor of Pathology, Director, UChicago Medical Laboratories, Director, Renal Pathology and Renal Pathology Fellowship, Associate Director, Pathology Residency Program, The University of Chicago, Chicago, Illinois and Lynn D. Cornell, MD , Associate Professor of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
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SECTION 1: INTRODUCTION AND OVERVIEW
4 Introduction to Renal Pathology
Robert B. Colvin, MD
24 Normal Kidney Structure
Neeraja Kambham, MD and Anthony Chang, MD
36 Normal Kidney Development
Sanjay Jain, MD, PhD and Yasar Caliskan, MD
46 Kidney Biopsy Evaluation and Reports
Lynn D. Cornell, MD, Surya V. Seshan, MD, and Anthony
Chang, MD
50 Harmonized Nephropathy Terminology
Mark Haas, MD
54 Common Artifacts and Pitfalls
Lynn D. Cornell, MD
SECTION 2: GLOMERULAR DISEASES
PODOCYTOPATHIES
60 Minimal Change Disease
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
68 Classification of Focal Segmental Glomerulosclerosis
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
72 Etiologic Classification of Focal Segmental
Glomerulosclerosis
Robert B. Colvin, MD
74 Focal Segmental Glomerulosclerosis, Primary
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
82 Focal Segmental Glomerulosclerosis, Adaptive
(Secondary)
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
88 Collapsing Glomerulopathy
A. Brad Farris, III, MD and Astrid Weins, MD, PhD
MEMBRANOUS NEPHROPATHY AND VARIANTS
98 Introduction to Membranous Nephropathy
Robert B. Colvin, MD
108 Etiologies of Membranous
Glomerulonephritis_Table
Robert B. Colvin, MD
110 Introduction to Membranous Nephropathy
Anthony Chang, MD
116 Mebranous Nephropathy Due to PLA2R
Autoantibodies
Anthony Chang, MD and Sanjeev Sethi, MD
120 Membranous Nephropathy Due to non-PLA2R
Antibodies
Anthony Chang, MD and Sanjeev Sethi, MD
124 Membranous Nephropathy Associated With
Systemic Disease
Anthony Chang, MD
128 Membranous Nephropathy With Organized Deposits
Anthony Chang, MD
132 Membranous Nephropathy With Anti-TBM
Antibodies
Robert B. Colvin, MD
134 Podocyte Infolding Glomerulopathy
Shane Meehan, MB, BCh
IGA-RELATED GLOMERULONEPHRITIS
136 Overview of IgA-Related Glomerular Diseases
Shane Meehan, MB, BCh
140 IgA Nephropathy
Lynn D. Cornell, MD, Robert B. Colvin, MD, and Ian Roberts, MBChB, FRCPath
154 IgA Vasculitis (Henoch-Schönlein Purpura)
Anthony Chang, MD and Ian Roberts, MBChB, FRCPath
160 IgA Acute Glomerulonephritis Associated With
Staphylococcus aureus
Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath
164 Hepatic Disease With IgA Deposition
Robert B. Colvin, MD
SLE AND RELATED AUTOANTIBODYMEDIATED DISEASES
166 Systemic Lupus Erythematosus
Shane Meehan, MB, BCh, Robert B. Colvin, MD, and Ingeborg Bajema, MD
184 Mixed Connective Tissue Disease
A. Brad Farris, III, MD
186 Idiopathic Nonlupus Full-House Nephropathy
Ingeborg Bajema, MD and Emilie Rijnink, MD, PhD
188 Mixed Cryoglobulinemic Glomerulonephritis
A. Brad Farris, III, MD and Charles Alpers, MD
ANTI-GBM DISEASES
194 Anti-GBM Glomerulonephritis
Anthony Chang, MD
202 Atypical Anti-GBM Disease
Lynn D. Cornell, MD
COMPLEMENT-RELATED GLOMERULONEPHRITIS
206 Classification of MPGN and Complement-Related Diseases
Robert B. Colvin, Md 210 Dense Deposit Disease
A. Brad Farris, III, MD
216 C3 Glomerulonephritis
Lynn D. Cornell, MD
222 C1q Nephropathy
Neeraja Kambham, MD
228 C4 Glomerulopathy
Sanjeev Sethi, MD
232 MPGN With Immune Complexes
A. Brad Farris, III, MD, Jean Hou, MD, and Mark Haas, MD
MONOCLONAL IMMUNOGLOBULIN DISEASES OF GLOMERULI
240 Introduction to Diseases With Monoclonal
Immunoglobulin Deposits
Robert B. Colvin, MD
244 Monoclonal Immunoglobulin Deposition Disease
Lynn D. Cornell, MD
252 Proliferative Glomerulonephritis With Monoclonal
IgG Deposits
Lynn D. Cornell, MD
256 Membranous Glomerulonephritis With Masked IgG ?
Deposits
Christopher P. Larsen, MD and Tiffany Caza, MD
260 Type I Cryoglobulinemic Glomerulonephritis
Robert B. Colvin, MD and Evan Farkash, MD, PhD
264 Waldenström Macroglobulinemia
Anthony Chang, MD
266 Crystalglobulin Glomerulonephritis
Anthony Chang, MD and Mariam Priya Alexander, MD
AMYLOIDOSIS
270 Amyloidosis Classification
A. Brad Farris, III, MD and Sanjeev Sethi, MD
276 AL/AH Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
282 AA Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
286 AFib Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
288 AGel Amyloidosis
Sanjeev Sethi, MD
290 ALECT2 Amyloidosis
Christopher P. Larsen, MD, Sanjeev Sethi, MD, and Tiffany Caza, MD
292 AApoAI Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
293 AApoAII Amyloidosis
Robert B. Colvin, MD and Sanjeev Sethi, MD
294 AApoAIV Amyloidosis
Sanjeev Sethi, MD
295 AApoCII Amyloidosis
Sanjeev Sethi, MD
296 ATTR Amyloidosis
A. Brad Farris, III, MD and Sanjeev Sethi, MD
IDIOPATHIC FIBRILLARY GLOMERULOPATHIES
298 Diseases With Organized Deposits
Robert B. Colvin, MD
302 Fibrillary Glomerulopathy
Anthony Chang, MD
308 Immunotactoid Glomerulopathy
Anthony Chang, MD and Charles Alpers, MD
312 Fibronectin Glomerulopathy
Neeraja Kambham, MD
DIABETIC AND RELATED RENAL DISEASE
316 Diabetic Nephropathy
Neeraja Kambham, MD and Ian Roberts, MBChB, FRCPath