This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.
Key Features
Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow; myelodysplastic syndrome (MDS) mimics; blood and bone marrow findings linked to targeted therapies; blood and bone marrow findings linked to other medications; and more Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow Includes details from the WHO’s fifth edition Classification of Tumours of Haematopoietic and Lymphoid Tissues as well as the International Consensus Classification of Hematolymphoid Neoplasms, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration Clearly delineates numerous genetic disorders often found in blood and bone marrow Features nearly 2,600 superb images (many new or updated), including histology and gross pathology photographs, full-color illustrations and schematics, clinical photographs, and radiologic images Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
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2 Introduction 3 Hematopoiesis and Bone Marrow Histology 4 Bone Marrow Examination and Techniques 5 Synoptic Bone Marrow Reporting 6 Overview of Constitutional and Acquired Bone Marrow Disorders 7 Anemia 8 Overview of Anemia 9 Acquired Anemias 10 Anemias of Inflammation, Chronic Renal Disease, and Cancer 11 Iron Deficiency Anemia 12 Autoimmune Hemolytic Anemias 13 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn 14 Microangiopathic Hemolytic Anemia 15 Megaloblastic Anemia 16 Acquired Nonneoplastic Sideroblastic Anemia 17 Alcoholism-Associated Anemia 18 Anemia in the Elderly 19 Copper Deficiency-Associated Anemia 20 Acquired Red Cell Aplasia 21 Transient Erythroblastopenia of Childhood 22 Parvovirus-Induced Red Cell Aplasia 23 Paroxysmal Nocturnal Hemoglobinuria 24 Acquired Aplastic Anemia 25 Constitutional Anemias 26 Thalassemia 27 Sickle Cell Anemia 28 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency 29 Pyruvate Kinase Deficiency 30 Hereditary Spherocytosis 31 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis 32 Diamond-Blackfan Anemia 33 Fanconi Anemia 34 Congenital Dyserythropoietic Anemia 35 Congenital Sideroblastic Anemia 36 Congenital Megaloblastic Anemia 37 Erythrocytosis 38 Constitutional 39 Congenital Erythrocytosis 40 Acquired 41 Acquired Erythrocytosis 42 Benign Leukocyte Disorders in Blood and Bone Marrow 43 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow 44 Pancytopenia 45 Neutropenia 46 Neutrophilia 47 Monocytosis 48 Eosinophilia 49 Basophilia 50 Lymphocytosis 51 Lymphopenia, Constitutional and Acquired 52 Plasmacytosis of Bone Marrow 53 Hematogones in Bone Marrow 54 Lymphoid Aggregates in Bone Marrow 55 Granulomas in Bone Marrow 56 Constitutional Granulocytic Disorders 57 Constitutional Neutropenias 58 Severe Congenital Neutropenia and Cyclic Neutropenia 59 Shwachman-Diamond Syndrome 60 Chediak-Higashi Syndrome 61 Myelokathexis in WHIM Syndrome 62 Constitutional Neutrophil Anomalies 63 Pelger-Huët Anomaly 64 *MYH9*-Related Disorders 65 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation 66 Megakaryocytic Disorders 67 Overview of Megakaryocytic Disorders 68 Acquired Platelet Disorders With Thrombocytopenia 69 Immune-Mediated Thrombocytopenia 70 Hemolytic-Uremic Syndrome 71 Heparin-Induced Thrombocytopenia (HIT) 72 Thrombotic Thrombocytopenic Purpura 73 Pregnancy-Associated Thrombocytopenia 74 Constitutional Platelet Disorders With Thrombocytopenia 75 Macrothrombocytopenia 76 Thrombocytopenia Absent Radius Syndrome 77 Congenital Amegakaryocytic Thrombocytopenia 78 Gray Platelet Syndrome 79 Wiskott-Aldrich Syndrome-Related Disorders 80 Congenital Thrombotic Thrombocytopenic Purpura 81 Thrombocytosis 82 Thrombocytosis 83 Infection 84 Overview of Infection 85 Hantavirus Pulmonary Syndrome 86 Human Immunodeficiency Virus 87 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus) 88 Parvovirus B19 Infection 89 Bacterial Infections, Blood and Bone Marrow Features 90 Fungal Infections, Blood and Bone Marrow Features 91 Helminthic Infections 92 Malaria 93 Other Protozoan Infections 94 COVID-19 Infection 95 Miscellaneous Nonneoplastic Disorders and Conditions 96 Overview and Classification of Hemophagocytic Disorders in Bone Marrow 97 Hematologic Manifestations of Collagen Vascular Disorders 98 Hematologic Manifestations of Chronic Renal Disorders 99 Lysosomal Storage Diseases With Predominantly Histiocytic Storage 100 Homeopathic Remedies and Medications Affecting Blood and Bone Marrow 101 Other Pregnancy-Associated Hematologic Disorders 102 VEXAS Syndrome 103 Gelatinous Transformation and Other Bone Marrow Stromal Disorders 104 Crystals in Bone Marrow 105 Bone Abnormalities in Bone Marrow Specimens 106 Myeloid Neoplasms 107 Overview and Classification of Myeloid Neoplasms 108 Specialized Testing in Myeloid Neoplasms 109 Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia 110 Myeloproliferative Neoplasms 111 Overview of Myeloproliferative Neoplasms 112 Chronic Myeloid Leukemia, *BCR-ABL1* Positive 113 Chronic Neutrophilic Leukemia 114 Polycythemia Vera 115 Primary Myelofibrosis 116 Essential Thrombocythemia 117 Chronic Eosinophilic Leukemia, Not Otherwise Specified 118 Myeloproliferative Neoplasm, Unclassifiable 119 Mastocytosis 120 Systemic Mastocytosis 121 Mast Cell Leukemia 122 Myeloid and Lymphoid Neoplasms With Eosinophilia and Gene Rearrangements 123 Myeloid and Lymphoid Neoplasms With *PDGFRA* Rearrangement 124 Myeloid and Lymphoid Neoplasms With *PDGRFB* Rearrangement 125 Myeloid and Lymphoid Neoplasms With *FGFR1* Rearrangement 126 Myeloid and Lymphoid Neoplasms With *FLT3* Rearrangement 127 Myelodysplastic/Myeloproliferative Neoplasms 128 Overview of Myelodysplastic/Myeloproliferative Neoplasms 129 Chronic Myelomonocytic Leukemia 130 Atypical Chronic Myeloid Leukemia, *BCR-ABL1* Negative (aCML) 131 Juvenile Myelomonocytic Leukemia 132 Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis 133 Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable 134 Myelodysplastic Syndromes 135 Overview and Classification of Myelodysplastic Syndromes 136 Clonal Hematopoiesis of Indeterminant Potential (CHIP) 137 Myelodysplastic Syndrome With Single Lineage Dysplasia 138 Myelodysplastic Syndromes With Ring Sideroblasts 139 Myelodysplastic Syndrome With Multilineage Dysplasia 140 Myelodysplastic Syndromes With Excess Blasts 141 Myelodysplastic Syndrome With Isolated del(5q) 142 Myelodysplastic Syndrome, Unclassifiable 143 Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood) 144 Acute Myeloid Leukemia 145 Overview of Acute Myeloid Leukemia 146 Familial AML/MDS (Germline Predisposition) 147 Acute Myeloid Leukemia With t(8;21)(q22;q22.1), *RUNX1-RUNX1T1* 148 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), *CBFB-MYH11* 149 Acute Promyelocytic Leukemia With *PML-RARA* 150 Acute Promyelocytic Leukemia With Variant *RARA* Rearrangement 151 Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3), *KMT2A-MLLT3* 152 Subtypes of Acute Myeloid Leukemia: t(6;9), inv(3), t(1;22), t(9;22), Mutated *NPM1,* Biallelic Mutated *CEBPA,* Mutated *RUNX1* 153 Acute Myeloid Leukemia With Myelodysplasia-Related Changes 154 Therapy-Related Myeloid Neoplasms 155 Acute Myeloid Leukemia With Minimal Differentiation (AML, NOS) 156 Acute Myeloid Leukemia Without Maturation (AML, NOS) 157 Acute Myeloid Leukemia With Maturation (AML, NOS) 158 Acute Myelomonocytic Leukemia (AML, NOS) 159 Acute Monoblastic and Monocytic Leukemia (AML, NOS) 160 Pure Erythroid Leukemia (AML, NOS) 161 Acute Megakaryoblastic Leukemia, Not Otherwise Specified 162 Acute Basophilic Leukemia (AML, NOS) 163 Acute Panmyelosis With Myelofibrosis (AML, NOS) 164 Myeloid Proliferations Related to Down Syndrome 165 Measurable Residual Disease Testing Strategies in AML 166 Blastic Plasmacytoid Dendritic Cell Neoplasm 167 Blastic Plasmacytoid Dendritic Cell Neoplasm 168 Acute Leukemias of Ambiguous Lineage 169 Acute Undifferentiated Leukemia 170 Mixed Phenotype Acute Leukemia 171 Lymphoid Neoplasms 172 Overview of Lymphoid Neoplasms 173 Specialized Testing in Lymphoid Neoplasms 174 B-Precursor Neoplasms 175 B-Lymphoblastic Leukemia 176 Novel Genetic Subtypes of B-Lymphoblastic Leukemia 177 BCR-ABL1-Like ALL 178 Measurable Residual Disease Testing Strategies in ALL 179 T-Precursor Neoplasms 180 T-Lymphoblastic Leukemia/Lymphoma 181 Early T-Cell Precursor Acute Lymphoblastic Leukemia 182 Mature B-Cell Neoplasms 183 Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Lymphomas 184 Monoclonal B-Cell Lymphocytosis 185 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 186 B-Cell Prolymphocytic Leukemia 187 Splenic Marginal Zone Lymphoma 188 Hairy Cell Leukemia 189 Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant 190 Lymphoplasmacytic Lymphoma 191 Gamma Heavy Chain Disease 192 Monoclonal Gammopathy of Undetermined Significance 193 Plasma Cell Myeloma 194 Burkitt Leukemia/Lymphoma 195 Mantle Cell Lymphoma in Blood and Bone Marrow 196 Follicular Lymphoma in Blood and Bone Marrow 197 Marginal Zone Lymphoma in Blood and Bone Marrow 198 Large B-Cell Lymphomas in Blood and Bone Marrow 199 Mature T-/NK-Cell Neoplasms 200 Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow 201 T-Cell Prolymphocytic Leukemia 202 T-Cell Large Granular Lymphocytic Leukemia 203 Chronic Lymphoproliferative Disorder of NK Cells 204 Aggressive NK-Cell Leukemia 205 Adult T-Cell Leukemia 206 Mycosis Fungoides/Sézary Syndrome 207 Anaplastic Large Cell Lymphoma in Blood and Bone Marrow 208 Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow 209 Hodgkin Lymphoma in Bone Marrow 210 Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte-Predominant Subtypes 211 Other Neoplasms Involving Bone Marrow 212 Langerhans Cell Histiocytosis in Bone Marrow 213 Posttransplant Lymphoproliferative Disorders in Bone Marrow 214 Metastatic Carcinoma and Sarcoma 215 CAP Protocol 216 Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms
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