For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research. Features a completely reorganized, single volume format, with more than 60 concise chapters covering all kidney diseases Provides comprehensive yet concise information on pathology, differential diagnosis and clinicopathologic correlations, as well as useful overviews of pathogenesis, demographics/epidemiology, and relevant clinical presentation, treatment, and outcomes Contains numerous diagnostic algorithms throughout Offers clinically oriented, quick-reference content on patterns of injury and classification
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Contributors vii Preface ix Tribute xi Preface to the First Edition (1966) xiii Acknowledgments xv SECTION 1 Introduction to Kidney Pathology 1 1.1 Kidney Pathology History and Kidney Biopsy Methods 2 J. Charles Jennette, Vivette D. D’Agati, M. Barry Stokes, Agnes B. Fogo, and Volker Nickeleit 1.2 Primer on the Pathologic Classification and Diagnosis of Kidney Disease 8 J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit, and M. Barry Stokes SECTION 2 Kidney Anatomy, Histology, and Development 43 2.1 Kidney Anatomy and Histology 44 William L. Clapp 2.2 Kidney Development 143 Filipa M. Lopes and Adrian S. Woolf SECTION 3 Kidney Congenital Anomalies and Cystic Diseases 169 3.1 Patterns of Injury, Terminology, and Classification of Kidney Congenital Anomalies and Cystic Diseases 170 Helen Liapis and J. Charles Jennette 3.2 Kidney Congenital Anomalies Including Dysplasia 177 Helen Liapis and Sanjay Jain 3.3 Cystic Kidney Disease 195 Helen Liapis and Bharathi V. Reddy SECTION 4 Glomerular Disease Associated With Proteinuria and Nephrotic Syndrome 215 4.1 Patterns of Injury, Terminology, and Classification of Glomerular Diseases Associated With Proteinuria and Nephrotic Syndrome 216 Vivette D. D’Agati and J. Charles Jennette 4.2 Minimal Change Disease 234 M. Barry Stokes 4.3 Focal Segmental Glomerulosclerosis 275 Vivette D. D’Agati and M. Barry Stokes 4.4 Membranous Nephropathy 334 Glen S. Markowitz, Sanjeev Sethi, and Vivette D. D’Agati 4.5 Amyloidosis 391 Maria M. Picken and Guillermo A. Herrera 4.6 Monoclonal Immunoglobulin-Related Glomerular Disease 424 Sanjeev Sethi, Fernando C. Fervenza, and Samih H. Nasr 4.7 Immunotactoid Glomerulopathy 466 Samih H. Nasr, Fernando C. Fervenza, and Sanjeev Sethi 4.8 Diabetic Kidney Disease 477 Behzad Najafian and Charles E. Alpers 4.9 Idiopathic Nodular Glomerulosclerosis 518 M. Barry Stokes and Vivette D. D’Agati 4.10 Metabolic and Storage Disease Glomerulopathies 526 Laura S. Finn 4.11 Fibronectin Glomerulopathy 560 Megan Troxell and Neeraja Kambham 4.12 Collagenofibrotic Glomerulopathy and Nail-Patella Syndrome 567 Laura S. Finn and Agnes B. FogoSECTION 5 Glomerular Disease Associated With Hematuria and Nephritic Syndrome 577 5.1 Patterns of Injury, Terminology, and Classification of Glomerular Diseases Associated With Hematuria and Nephritic Syndrome 578 J. Charles Jennette and Vivette D. D’Agati 5.2 IgA Nephropathy and IgA Vasculitis (Henoch-Schönlein Purpura) Nephritis 591 Mark Haas 5.3 Lupus Nephritis and Related Autoimmune Diseases 661 Vivette D. D’Agati and M. Barry Stokes 5.4 Fibrillary Glomerulonephritis 740 Kelly D. Smith 5.5 Cryoglobulinemic Glomerulonephritis 750 Ian W. Gibson and Volker Nickeleit 5.6 Acute Post-infectious Glomerulonephritis and Infection-Associated Glomerulonephritis 763 Anjali A. Satoskar and Tibor Nadasdy 5.7 C3 Glomerulopathy 823 H. Terence Cook and Matthew C. Pickering 5.8 Anti–Glomerular Basement Membrane Disease 848 J. Charles Jennette and Ingeborg M. Bajema 5.9 Antineutrophil Cytoplasmic Autoantibody Disease 874 J. Charles Jennette and Ingeborg M. Bajema 5.10 Alport Syndrome/Type IV Collagen Nephropathies 903 Agnes B. Fogo SECTION 6 Kidney Vasculopathies 923 6.1 Patterns of Injury, Classification, and Diagnostic Algorithm of Kidney Vasculopathies 924 M. Barry Stokes and J. Charles Jennette 6.2 Kidney Disease Related to Hypertension and Age 937 Agnes B. Fogo 6.3 Fibromuscular Dysplasia 967 Surya V. Seshan and J. Charles Jennette 6.4 Thrombotic Microangiopathies 973 Kerstin Amann and Agnes B. Fogo 6.5 Preeclampsia and Other Pregnancy- Associated Kidney Disease 1033 Agnes B. Fogo 6.6 Disseminated Intravascular Coagulation 1068 Kerstin Amann and Agnes B. Fogo 6.7 Atherosclerosis and Embolic Kidney Disease 1071 Hans-Joachim Anders and Agnes B. Fogo 6.8 Polyarteritis Nodosa, Kawasaki Disease, Takayasu Arteritis, and Giant Cell Arteritis 1078 Surya V. Seshan and J. Charles Jennette SECTION 7 Tubulointerstitial Disease 1107 7.1 Patterns of Injury, Terminology, and Classification of T ubulointerstitial Disease 1108 Agnes B. Fogo and J. Charles Jennette 7.2 Infection-Related T ubulointerstitial Nephritis 1122 Megan Troxell and Neeraja Kambham 7.3 Noninfectious T ubulointerstitial Nephritis 1168 Cynthia C. Nast and Agnes B. Fogo 7.4 IgG4-Related Disease 1204 Lynn D. Cornell 7.5 Chronic Interstitial Nephritis in Agricultural Communities (Mesoamerican Nephropathy, CKDu) and Aristolochic Acid Nephropathy (Balkan Endemic Nephropathy) 1216 Cynthia C. Nast and Marc E. De Broe 7.6 Nephronophthisis, Medullary Cystic Disease, and Other Genetic T ubular Disease 1232 Laura S. Finn 7.7 Ischemic and Septic Acute T ubular Injury and Cortical Necrosis 1262 Joseph P . Gaut 7.8 Nephrotoxic Acute T ubular Injury 1284 Gilbert W. Moeckel 7.9 Light Chain Tubulopathies 1310 M. Barry Stokes 7.10 Light Chain (Myeloma) Cast Nephropathy and Mimics 1317 Virginie Royal and Guillermo A. Herrera 7.11 Myoglobin, Hemoglobin, and Bile Cast Nephropathies, and Anticoagulant Nephropathy 1329 Joseph P . Gaut, Sergey V. Brodsky, and Tibor Nadasdy 7.12 Nephrolithiasis and Crystallopathies 1344 Laura S. Finn and Hans-Joachim Anders 7.13 Obstructive and Reflux Nephropathy 1366 Lois J. Arend SECTION 8 Transplant Pathology 1383 8.1 Patterns of Injury, Terminology, and Classification of Kidney T ransplant Disease 1384 Volker Nickeleit and J. Charles Jennette 8.2 Kidney Allograft Biopsy: Overview 1393 Volker Nickeleit 8.3 Donor Kidney Biopsies 1396 Harsharan K. Singh and Volker Nickeleit 8.4 Kidney Transplant Rejection 1402 Volker Nickeleit, Robert B. Colvin, and Peter Nickerson 8.5 Kidney T ransplant Ischemic Injury 1479 Parmjeet Randhawa 8.6 Kidney T ransplant: Drug T oxicity 1485 Volker Nickeleit and Parmjeet Randhawa 8.7 Kidney Transplant Infection 1501 Harsharan K. Singh and Volker Nickeleit 8.8 Recurrent and De Novo Disease 1521 Parmjeet Randhawa and Volker Nickeleit 8.9 Posttransplant Lymphoproliferative Disorders 1537 Parmjeet Randhawa and Volker Nickeleit 8.10 Kidney T ransplant: Surgical and Vascular Complications 1545 Parmjeet Randhawa and Volker Nickeleit SECTION 9 Kidney Neoplasms 1551 9.1 Patterns of Injury, Terminology, and Classification of Kidney Neoplasms 1552 John N. Eble, Liang Cheng, and J. Charles Jennette 9.2 Kidney Neoplasms in Children 1558 John N. Eble and Liang Cheng 9.3 Kidney Neoplasms in Adults 1567 John N. Eble and Liang Cheng Index 1601
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