의학서적전문 "성보의학서적"의 신간의학도서입니다.

Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource.

Key Features

Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.

Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.

Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies

Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.

Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.

Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.

Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.

Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.

Presents relevant basic science as background for clinical application in later sections.

An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.


Author Information

Edited by Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York ; Edward J. Benz, Jr., MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts; Leslie E. Silberstein, MD, Director, Transfusion Medicine, Professor of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachussetts ; Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas; Jeffrey Weitz, MD, Professor of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Heart and Stroke Foundation/J.F. Mustard Chair in Cardiovascular Research Canada Research Chair (Tier 1) in Thrombosis, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada ; Mohamed E. Salama, MD and Syed Ali Abutalib


-도서목차-

Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY


Chapter 1 Anatomy and Physiology of the Gene
Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner


Chapter 2 Genomic Approaches to the Study of Hematologic Science
Todd Golub and Scott Armstrong


Chapter 3 Protein Synthesis, Processing, and Degradation
Garabet G. Toby and David L. Wiest


Chapter 4 Protein Architecture: Relationship of Form and Function
Alan C. Rigby and Barbara C. Furie


Chapter 5 Regulation of Cellular Response
Benjamin G. Neel and Christopher Carpenter


Chapter 6 Cell Adhesion
Rodger P. McEver


Chapter 7 Control of Cell Division
William M.F. Lee and Chi V. Dang


Chapter 8 Cell Death
David M. Hockenbery and Stanley J. Korsmeyer


Chapter 9 Pharmacogenomics and Hematological Diseases
Loe Kager and William E. Evans


Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY


Chapter 10 Overview and Compartmentalization of the Immune System
Leland D. Powell and Linda G. Baum


Chapter 11 B-Cell Development
Kenneth Dorshkind and David J. Rawlings


Chapter 12 T-Cell and NK-Cell Immunity
Carol Clayberger and Alan M. Krensky


Chapter 13 Dendritic Cell Biology
Zbigniew M. Szczepiorkowski and Nina Bhardwhaj


Chapter 14 Regulation of Activation of B and I Lymphocytes
John C. Monroe and Lawrence Turka


Chapter 15 Leukocyte Trafficking
James J. Campbell, Steven Sloan, and Leslie E. Silberstein


Chapter 16 Tolerance and Autoimmunity
Mark J. Shlomchik


Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS


Chapter 17 Stem Cell Model of Hematopoiesis
Anskar YH Leung and Catherine M. Verafaillie


Chapter 18 Bone Marrow Microenvironment
Mo Dao and Catherine M. Verfaillie


Chapter 19 The Humeral Regulation of Hematopoiesis
Montaser Shaheen and Hal Broxmeyer


Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Thalia Papayannopoulou, Alan D’Andrea, Janis Abkowitz, and Anna Rita Migliaccio


Chapter 21 Granulopoiesis and Monocytopoiesis
Arati Khanna-Gupta and Nancy Berliner


Chapter 22 Thrombocytopoiesis
Michael W. Long and Ronald Hoffman


Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
J. B. Opalinska and Alan M. Gewirtz


Chapter 24 Inherited Forms of Bone Marrow Failure
Melvin H. Freedman


Chapter 25 Aplastic Anemia
Neal S. Young and Jaroslaw P. Maciejewski


Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
Rob A. Brodsky


Chapter 27 Pure Red Cell Aplasia
Emmanuel N. Dessypris


Part IV. RED BLOOD CELLS


Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert


Chapter 29 Approach to Anemia in the Adult and Child
Peter Marks and Bertil Glader


Chapter 30 Anemia of Chronic Diseases
Lawrence B. Gardner and Edward J. Benz, Jr.


Chapter 31 Pathology of Iron Metabolism
Nancy C. Andrews


Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload
Gary M. Brittenham


Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
James S. Wiley and Michael R. Moore


Chapter 34 Megablastic Anemias
Aœok C. Anthony


Chapter 35 Thalassemia Syndromes
Bernard G. Forget and Alan R. Cohen


Chapter 36 Pathology of Sickle Cell Disease
Robert P. Hebbel


Chapter 37 Sickle Cell Disease
Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah


Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and
Methemoglobinemias
Edward J. Benz, Jr.


Chapter 39 Red Cell Enzymopathies
Xylina T. Gregg and Josef T. Prchal


Chapter 40 Red Cell Membrane Disorders
Patrick G. Gallagher and Petr Jarolim


Chapter 41 Autoimmune Hemolytic Anemias
Melody J. Cunningham and Leslie E. Silberstein


Chapter 42 Extrinsic Nonimmune Hemolytic Anemias
Stanley L. Schrier and Erin Gourley Reid


Part V. HOST DEFENSE AND ITS DISORDERS


Chapter 43 Complement Biology and Immunoglobulin
Gregory Kline, Robert Barrington, and Michael C. Carroll


Chapter 44 Normal Phagocyte Structure and Function
Robert L. Baehner


Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Steven J. Ackerman and Joseph H. Butterfield


Chapter 46 Disorders of Phagocyte Function and Number
Mary C. Dinauer and Thomas D. Coates


Chapter 47 Disorders of Lymphocyte Function
Aileen M. Cleary, Richard A. Insel, and David B. Lewis


Chapter 48 Histiocytic Disorders
Jeffrey M. Lipton and Robert J. Arceci


Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
Gregory A. Grabowski and Nancy Leslie


Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop


Chapter 51 The Spleen and Its Disorders
Susan B. Shurin


Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis
Robert I. Parker and Dean D. Metcalfe


Part VI. HEMATOLOGIC MALIGNANCIES


Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological
Malignancies
Gordon Dewald and Rhett P. Ketterling


Chapter 54 The Molecular Basis of Neoplasia
Carol Westbrook


Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis



Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
Andrea K. Ng and Peter M. Mauch


Chapter 57 Clinical Use of Hematopoietic Growth Factors
Jacob M. Rowe and Irit Avivi


Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Thomas E. Witzig


Chapter 59 Pathobiology of Acute Myeloid Leukemia
Brian Huntly and D. Gary Gilliland


Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
Kenneth B. Miller and Philip R. Daoust


Chapter 61 Therapy for Acute Myeloid Leukemia
Elihu H. Estey and Hagop Kantarijan


Chapter 62 Acute Myeloid Leukemia in Children
Gary V. Dahl and Howard J. Weinstein


Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
A. Thomas Look and Adolpho Ferrando


Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
Stacey L. Berg, C. Philip Steuber, and David G. Poplack


Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen


Chapter 66 Acute Lymphoblastic Leukemia in Adults
Dieter Hoelzer and Nicola Gokbudget


Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
Richard Stone and Daniel DeAngelo


Chapter 68 Polycythemia Vera
Ronald Hoffman, Kelty R. Baker and Joe Prchal


Chapter 69 Chronic Myeloid Leukemia
Charles Sawyers and Neil P. Shah


Chapter 70 Myelofibrosis with Myeloid Metaplasia
Ronald Hoffman and Farhad Ravandi-Kashani


Chapter 71 Essential Thrombocythemia
Steven Fruchtman and Ronald Hoffman


Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz


Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
Gianluca Gaidano and Riccardo Dalla-Favera


Chapter 74 Patho-Biology of Hodgkin’s Lymphoma
Stefano A. Pileri, Brunangelo Falini and Harold Stein


Chapter 75 Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy
Volker Diehl, Daniel Re, and Andreas Josting


Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Elaine Jaffe and Stefania Piltaluga


Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce


Chapter 78 Malignant Lymphomas in Childhood
John T. Sandlund, Jr.Michael P. Link


Chapter 79 Chronic Lymphocytic Leukemia
Dilip V. Patel and Kanti R. Rai


Chapter 80 Hairy Cell Leukemia
Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman


Chapter 81 Cutaneous T-Cell Lymphomas
Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen


Chapter 82 AIDS-Related Lymphomas
David T. Scadden


Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
Guido Tricot


Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien


Chapter 85 Atypical Immune Lymphoproliferations
Timothy C. Greiner and Thomas G. Gross


Chapter 86 Clinical Approaches to Infections in the Compromised Host
Jo-Anne H. van Burik


Chapter 87 Nutritional Support of Patients with Hematologic Malignancies
Polly Lenssen and Saundra N. Aker


Chapter 88 Psychosocial Aspects of Hematologic Disorders
Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta


Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders
Janet L. Abrahm, Lauren Dias, and Bridget Fowler


Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes


Chapter 91 Indwelling Access Devices
Janet L. Abrahm and Linda M. Pellerin


Chapter 92 Late Complications of Hematologic Diseases and Their Therapies
Wendy Landier and Smita Bhatia


Part VII. TRANSPLANTATION


Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
William Tse and H. Joachim Deeg


Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
Stella M. Davies


Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Andrea Bacigalupo


Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors
Stephen J. Forman and Jeffery R. Schriber


Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy
Effie W. Petersdorf and Claudio Anasetti


Chapter 98 Umbilical Cord Blood Transplantation
Juliet N. Barker and John E. Wagner


Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation
Marcos de Lima and Sergio Giralt


Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia
Pavan Reddy and James L.M. Ferrara


Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
Catherine M. Bollard and Adrian P. Gee


Chapter 102 Gene Transfer for Hematologic Disorders
Katherine A. High and Malcolm K. Brenner


Chapter 103 Experimental Cell Therapy
Robert S. Negrin


Chapter 104 Complications After Hematopoietic Cell Transplantation
Daniel J. Weisdorf


Part VIII. HEMOSTASIS AND THROMBOSIS


Chapter 105 Megakaryocyte and Platelet Structure
Joseph E. Italiano and John Hartwig


Chapter 106 The Molecular Basis for Platelet Function
Edward F. Plow and Charles S. Abrams


Chapter 107 The Molecular Basis for Platelet Activation
Lawrence F. Brass


Chapter 108 The Blood Vessel Wall
Aly Karsan and John M. Harlan


Chapter 109 Molecular Basis of Blood Coagulation
Bruce Furie and Barbara C. Furie


Chapter 110 Molecular and Cellular Basis of Fibrinolysis
H. Roger Lijnen and Désiré Collen


Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Charles T. Esmon


Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential
Diagnosis of Pupura
Barry S. Coller and Paul I. Schniederman


Chapter 113 Laboratory Evaluation of Hemostatic Disorders
Jacob H. Rand and Lisa Senzel



Chapter 114 Structure, Biology, and Genetics of Factor VIII
Randal J. Kaufman and Stylianos E. Antonarakis


Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B
S. Jamie Freedman and Bruce Furie


Chapter 116 Clinical Aspects and Therapy of Hemophilia
Jay Nelson Lozier and Craig M. Kessler


Chapter 117 Inhibitors in Hemophilia
Donald I. Feinstein


Chapter 118 Other Clotting Factor Deficiencies
Harold R. Roberts and Miguel A. Escobar


Chapter 119 Disorders of Fibrinogen
José Martinez and Andres Ferber


Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor
David Ginsburg and Denisa D. Wagner


Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy
Gilbert C. White, II, and J. Evan Sadler


Chapter 122 Vitamin K: Metabolism and Disorders
Barbara C. Furie and Bruce Furie


Chapter 123 Inhibitors of Blood Coagulation
Donald I. Feinstein


Chapter 124 Disseminated Intrvascular Coagulation
Howard A. Liebman and Ilene C. Weitz


Chapter 125 Hemostatic Defects Associated with Dysproteinemias
Howard A. Liebman


Chapter 126 Disorders of Coagulation in the Neonate
Leonardo R. Brandao and Donna DiMichele


Chapter 127 Hypercoagulable States
Kenneth A. Bauer


Chapter 128 Venous Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg


Chapter 129 Arterial Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg


Chapter 130 Anticoagulation and Thrombolytic Therapy
Jeffrey I. Weitz


Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune
Thrombocytopenia, and Posttransfusion Purpura
James Bussel and Douglas Cines


Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
Keith R. McCrae, J Evan Sadler, and Douglas Cines


Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Theodore E. Warkentin and John G. Kelton


Chapter 134 Hereditary Disorders of Platelet Function
Joel S. Bennett


Chapter 135 Acquired Disorders of Platelet Function
Jose Lopez and Perumal Thiagarajan


Part IX. TRANSFUSION MEDICINE


Chapter 136 Human Blood Group Anitgens and Antibodies
Part 1: Carbohydrate Determinants
Part 2: Protein Determinants
Marion E. Reid and Martin L. Olsson


Chapter 137 Human Platelet Antigens
Thomas J. Kunicki and Diane J. Nugent


Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek


Chapter 139 Principles of Red Blood Cell Transfusion
Paul M. Ness and Margot S. Kruskall


Chapter 140 Principles of Platelet Transfusion Therapy
Thomas S. Kickler


Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions
Ronald G. Strauss


Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,
Cryoprecipitate, Albumin, and Immunoglobulins
Cassandra D. Josephson and Christopher D. Hillyer


Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
William N. Drohan and David B. Clark


Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies
Catherine S. Manno and Peter Larson


Chapter 145 Hemapheresis and Cellular Therapy
Ellen F. Lazarus and Harvey G. Klein


Chapter 146 Practical Aspects of Stem Cell Collection
Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu


Chapter 147 Transfusion Reactions
Edward L. Snyder and YanYun Wu


Chapter 148 Transfusion-Transmitted Diseases
Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove


Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik


Chapter 150 Red Blood Cell Substitutes
Robert M. Winslow


Part X. CONSULTATIVE HEMATOLOGY


Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
Rachel Rosovsky and Peter W. Marks


Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
Peter W. Marks and David S. Rosenthal


Chapter 153 Hematologic Manifestations of AIDS
David H. Henry and James A. Hoxie


Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Mark T. Reding and Nigel S. Key


Chapter 155 Hematologic Aspects of Pregnancy
Edward J. Benz, Jr.


Chapter 156 Hematologic Manifestations of Childhood Illness
A. Kim Ritchey and Frank G. Keller


Part XI. SPECIAL TESTS AND PROCEDURES


Chapter 157 Bone Marrow Examination
Daniel H. Ryan and Harvey J. Cohen


Chapter 158 Automated Analysis of Blood Cells
Raymond E. Felgar and Daniel H. Ryan


Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias
Martin H. Steinberg and David Chui


Chapter 160 Antenatal Diagnosis of Hematologic Disorders
Kim Kramer and Harvey J. Cohen


Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases
Michele Paessler and Adam Bagg


Chapter 162 Molecular Imaging in Hematology
Francis G. Blankenberg


Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
Sharon M. Geaghan

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