의학서적전문 "성보의학서적"의 신간의학도서입니다.

Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

Key Features


Reviews the clinical aspects and subtypes of dementia
Explains molecular pathways involved in brain inflammation
Includes the role of CSF and blood in diagnosis
Covers established and novel neuroimaging methods
Discusses established and developing treatment strategies
Identifies future directions, such as machine learning and precision medicine


-도서목차-


Cover image
Title page
Table of Contents
Copyright

Chapter 1. Clinical aspects of diagnosis in dementia

Abstract
Introduction
Determining the etiology of cognitive decline
Neurodegenerative causes of dementia
Alzheimer’s disease
Vascular causes of dementia
Mixed dementia—AD and VCID
Normal pressure hydrocephalus
References

Chapter 2. Neuroimaging methods

Abstract
Historical perspective
Discovery of computerized axial tomography
Nuclear magnetic resonance spectroscopy and magnetic resonance imaging
Basic concepts in nuclear magnetic resonance
Diffusion tensor imaging
Advanced diffusion techniques: fiber tract connectivity with mean kurtosis and constrained spherical deconvolution
Detection of white matter injury
References

Chapter 3. Biomarkers in cerebrospinal fluid and blood aid diagnosis of dementia

Abstract
Pathologic deposition of misfolded proteins in the brain: amyloid, tau, α-synuclein, TDP-43
Biomarkers for amyloid in cerebrospinal fluid
Amyloid and tau
Biomarkers in mild cognitive impairment
Clinical and biological diagnosis of Alzheimer’s disease
Theories of Alzheimer’s disease: amyloid hypothesis
Alternative Alzheimer’s disease hypotheses: blood–brain barrier dysfunction
Positron emission tomography biomarkers
Blood-based biomarkers
Selection of biomarkers: cerebrospinal fluid versus blood
References

Chapter 4. Classification of subtypes of vascular dementia

Abstract
Definitions
Major types of vascular disease
Midlife hypertension and white matter injury
Blood vessels and sites of selective vulnerability
Monogenic forms of white matter disease
References

Chapter 5. Neuroinflammation

Abstract
Classic definition of inflammation
Inflammation in chronic hypoxic/ischemic disease
Consequences of reduced cerebral blood flow
Brain fluid interfaces
Extracellular matrix and the matrix metalloproteinases
Role of the metalloproteinases in the disruption of the blood–brain barrier
Angiogenesis
Cytokines
References

Chapter 6. Animal models for vascular cognitive impairment

Abstract
Introduction
Bilateral carotid artery occlusion in rat
Hypoxic hypoperfusion in mice
Ameroid constrictor bilateral carotid artery stenosis model
Spontaneously hypertensive rats
White matter injury in SHRSP
Blood-brain barrier opening and matrix metalloproteinases in SHRSP
Hypoxia in SHRSP
Mechanism of white matter injury in SHRSP
References

Chapter 7. Molecular pathways

Abstract
Introduction
Burden of disease in normals
Consequences of abnormal proteins in the brain
Neurovascular unit
Disruption of the neurovascular unit in dementia
DCE-MRI in cerebral small vessel disease
References

Chapter 8. Mechanisms of white matter injury

Abstract
White matter is the major site of pathology in vascular-mediated dementia
Myelin disruption in inflammation
Glutamate-mediated excitotoxicity
Inflammation in small vessel disease of the Binswanger’s type
Interaction of proteases, angiogenic factors, and cytokines
Bystander demyelination
References

Chapter 9. Machine learning and precision medicine

Abstract
Introduction
Machine learning
Approach of clinical medicine to diagnosis
Early attempts at improving diagnostic accuracy in dementia
NMR spectroscopy as a biomarker
Diffusion tensor imaging
Computer advances and big data
References

Chapter 10. Future directions

Abstract
Amyloid reconsidered
Advanced magnetic resonance imaging methods
Genetic studies on early- and late-onset Alzheimer’s disease
Early diagnosis of Alzheimer’s disease with measurement of Alzheimer’s disease proteins in plasma
Hypoxia and inflammation augment the amyloid theory of chronic subcortical dementia
Insights into pathophysiology of Binswanger’s disease
Will treatments aimed at reducing inflammation slow WM injury?
Can biomarker-driven precision medicine be integrated into clinical practice?
Neurology training in the future
References
Index


기타 의학도서에 관련된 문의사항은 고객센터(02-854-2738) 또는 저희 성보의학서적 홈페이지내 도서문의 게시판에 문의바랍니다.
감사합니다.
성보의학서적 "http://www.medcore.kr