의학서적전문 "성보의학서적"의 신간의학도서입니다.

Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
Covers the basic science clinicians need to know to understand the mechanisms of action of orthobiologic therapies for tissue repair and regeneration, as well as technology development, regulation, and the commercialization pathway
Provides thorough discussions of current standards of care and clinical applications across all subspecialty areas, including upper and lower extremity pathology, as well as spinal pathology
Uses a reader-friendly approach with more than 100 illustrations and dozens of helpful tables throughout
Discusses options and solutions for intervertebral disc repair, spinal fusion, rotator cuff repair, peripheral nerve regeneration in the hand, challenging bone repairs and nonunion, skeletal muscle repair, meniscal repair and replacement, articular cartilage repair, knee and ankle osteoarthritis, ligament regeneration, and more.
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-도서목차-

Editorial Board v
Contributors vii
Foreword xiii
Acknowledgments xv
Introduction xvii
PART 1: Foundational Principles
Section 1: Biologic Options for Tissue Repair and Regeneration
Section Editors: Robert E. Guldberg, PhD; Edward M. Schwarz, PhD; Christopher H. Evans, PhD
1 Cell Biology and Cell Sources ........................................................................5
Frank Barry, PhD; Mary Murphy, PhD, DSc
2 Materials Science and Biodegradable Scaffolds ........................................................17
Kenneth S. Ogueri, BS, MSc, PhD; Kevin Grassie, BS; Yusuf Khan, PhD; Cato T. Laurencin, MD, PhD, FAAOS
3 Bioactive Factors and Designer Molecules ............................................................33
Vicki Rosen, PhD
4 Gene Therapy ....................................................................................43
Steven C. Ghivizzani, PhD; Christopher H. Evans, PhD
5 Clinically Applicable and Translatable Animal Models in Orthobiologic Research for
Cartilage Repair and Osteoarthritis in Humans........................................................61
Laurie Goodrich, DVM, MS, PhD
6 Overview of Orthobiologics for Articular Cartilage Repair ..............................................85
Erica G. Gacasan, MS; Robert L. Sah, MD, ScD
7 Overview of Orthobiologics for Bone Repair .........................................................103
Mirtijn van Griensven, MD, PhD; Elizabeth Rosado Balmayor, PhD
8 Orthobiologics for Tendon and Ligament Repair ..................................................... 119
Hani Awad, PhD; Rahul Alenchery, MSc; Raquel Ajalik, MSc; Victor Z. Zhang, BSc
9 Summary and Perspectives ........................................................................141
Edward M. Schwarz, PhD; Christopher H. Evans, PhD; Robert E. Guldberg, PhD
Section 2 Technology Development, Regulation, and the Commercialization Pathway
Section Editors: Scott P . Bruder, MD, PhD, FORS; Anthony Ratcliffe, PhD
10 Pitfalls in the Assessment of Outcomes in Randomized Clinical Trials ...................................147
Joseph Harrington, BS; Jennifer Racine- Avila, MBA; Roy K. Aaron, MD, FAAOS, FORS
11 Measuring and Reporting Outcomes................................................................155
Joel J. Gagnier, ND, MSc, PhD; Matthew J. Hadad, MD; Nicolas S. Piuzzi, MD; Evangeline Fumina Kobayashi, MD
12 The US FDA Regulatory Landscape and Compliance..................................................169
Aric Kaiser, MS 13 Product Development ............................................................................185
Lara Ionescu Silverman, PhD; Daniel Rodriguez- Granrose, PhD; Niloofar Farhang, PhD;
Angelica Adrian Highsmith, MS
14 Allograft and Xenograft Tissue Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .195
Stephen F. Badylak, DVM, PhD, MD; Emily Dianne Henderson, BS
15 Product and Provider Reimbursement in the Field of Orthobiologics ....................................205
Spencer B. Bailey, MBA, CPC
16 Summary and Perspectives ........................................................................215
Anthony Ratcliffe, PhD; Scott P . Bruder, MD, PhD, FORS
PART 2: Clinical Applications
Section 3: Solutions for Upper Extremity Pathology
Section Editors: Kathleen A. Derwin, PhD; Adam Yanke, MD, PhD, FAAOS
17 Rotator Cuff Repair...............................................................................223
Scott A. Rodeo, MD, FAAOS; Janice Havasy, BS, MD; Claire D. Eliasberg, MD; Camila B. Carballo, PhD, PT
18 Tendon Management, Protection, and Repair ........................................................233
Allan Mishra, MD, FAAOS; Michael W. Heffner, MD; Christopher Frey, MD
19 Fresh Fracture, Challenging Bone Repair, and Nonunions .............................................245
J. Tracy Watson, MD, FAAOS
20 Peripheral Nerve Regeneration in the Hand .........................................................265
Minh Hoang Nguyen, MD; Amy M. Moore, MD; Ryan W. Schmucker, MD
21 Skeletal Muscle Regeneration ......................................................................277
George J. Christ, PhD; Brian C. Werner, MD, FAAOS; Sarah E. Dyer, BS; Shep Hurwitz, MD, FAAOS
22 Measurement of Clinical Outcomes in the Upper Extremity ............................................293
Vahid Entezari, MD, MSc; Jason C. Ho, MD; Joseph P . Iannotti, MD, PhD, FAAOS;
Kathleen A. Derwin, PhD; Eric T. Ricchetti, MD, FAAOS
23 Summary and Perspectives ........................................................................305
Adam Yanke, MD, PhD, FAAOS; Kevin Credille, BSE, MS; Mario Hevesi, MD, PhD; Kathleen A. Derwin, PhD
Section 4: Solutions for Lower Extremity Pathology
Section Editors: Robert H. Brophy, MD, FAAOS; Regis J. O’Keefe, MD, PhD, FAAOS
24 Segmental Defect Repair and Nonunion............................................................. 311
Joseph T. Patterson, MD; Jay R. Lieberman, MD, FAAOS
25 Meniscal Repair and Replacement ..................................................................327
Suhas P . Dasari, MD; Safa Gursoy, MD, PhD; Robert F . LaPrade, MD, PhD, F AAOS; Jorge Chahla, MD, PhD
26 Articular Cartilage Repair—Cells and Biomaterials ...................................................345
Michael J. Sayegh, MD; Daniel A. Grande, PhD; Nicholas A. Sgaglione, MD, FAAOS;
Kenneth R. Zaslav, MD, FAAOS
27 Knee and Ankle Osteoarthritis—Injectables ..........................................................359
Hannah Bradsell, BS; Rachel M. Frank, MD, FAAOS
28 Ligament Repair and Regeneration .................................................................369
Natalie L. Leong, MD, FAAOS; Jie Jiang, PhD
29 Clinical Outcomes in the Hip and Knee Following Arthroplasty ........................................381
Caroline Taber, AB; Robert G. Marx, MD, FAAOS; Alissa J. Burge, MD 30 Biologic Considerations for Clinical Study Design: Cartilage Repair.........................391
James L. Cook, DVM, PhD; David P . Trofa, MD; Clayton W. Nuelle, MD, FAAOS; Clark T. Hung, PhD
31 Summary and Perspectives ...........................................401
Robert H. Brophy, MD, FAAOS; Regis J. O’Keefe, MD, PhD, FAAOS
Section 5: Solutions for Spinal Pathology
Section Editors: Wellington K. Hsu, MD, FAAOS; Kevin C. Baker, PhD
32 Intervertebral Disk Repair and Regeneration—Bioactive Factors and Cell- Based Therapy ..................407
Koichi Masuda, MD; Koji Akeda, MD, PhD; Kenji Kato, MD, PhD; Jordy Schol, MSc; Daisuke Sakai, MD, PhD
33 Spine Fusion—Bioactive Factor Based...............................................................435
Hyun W. Bae, MD; Michael Eng, MD; Linda E. A. Kanim, MA; Justin D. Cohen, MD; Juliane Glaeser, PhD;
Julie L. Chan, MD, PhD
34 Measurement of Clinical Outcomes in Spine .........................................................469
Athan G. Zavras, BA, MD; Ishan Agarwal, BS; Bryce A. Basques, MD; Frank M. Phillips, MD, FAAOS
35 Biologic Considerations for Clinical Study Design: Fusion .............................................479
S. Raymond Golish, MD, PhD, MBA, FAAOS
36 Summary and Perspectives ........................................................................487
Kevin C. Baker, PhD; Wellington K. Hsu, MD, FAAOS
Index ...............................................................................................489


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