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The WHO Classification of Tumours, Thoracic Tumours is the fifth volume in the 5th edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The 5th edition, guided by the WHO Classification of Tumours Editorial Board, will establish a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumour type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? Pathologists, Oncologists, Respiratory physicians, Thoracic radiologists, Cancer researchers, Surgeons, Epidemiologists, Cancer registrars, This volume, Prepared by 217 authors and editors, Contributors from around the world, More than 1000 high-quality images, More than 3500 references, WHO Classification of Tumours Online, The content of this renowned classification series is now also available in a convenient digital format https://tumourclassification.iarc.who.int

-도서목차-

List of abbreviations xi

Foreword xii

ICD-O topographical coding 1

ICD-O morphological coding 1

Tumours of the lung 2

Tumours of the pleura and pericardium 4

Tumours of the heart 5

Mesenchymal tumours of the thorax 6

Tumours of the thymus 7

Germ cell tumours of the mediastinum 8

Haematolymphoid tumours of the mediastinum 8

Ectopic tumours of thyroid and parathyroid origin 9

TNM staging of lung, pleural, and thymic tumours 10

Carcinomas of the lung 11

Pleural mesothelioma 13

Epithelial tumours of the thymus 14

TNM staging of tumours of soft tissues 15

Staging of Hodgkin and non-Hodgkin lymphomas 17

1 Tumours of the lung 19

Introduction 20

Small diagnostic samples 29

Epithelial tumours

Papillomas

Bronchial papillomas 37

Adenomas

Sclerosing pneumocytoma 41

Alveolar adenoma 44

Papillary adenoma 46

Bronchiolar adenoma / ciliated muconodular papillary tumour 48

Mucinous cystadenoma 51

Mucous gland adenoma 53

Precursor glandular lesions

Atypical adenomatous hyperplasia 55

Adenocarcinoma in situ 57

Adenocarcinomas

Minimally invasive adenocarcinoma 60

Invasive non-mucinous adenocarcinoma 64

Invasive mucinous adenocarcinoma 75

Colloid adenocarcinoma 79

Fetal adenocarcinoma 81

Enteric-type adenocarcinoma 83

Squamous precursor lesions

Squamous dysplasia and carcinoma in situ 85

Squamous cell carcinomas

Squamous cell carcinoma 89

Lymphoepithelial carcinoma 94

Large cell carcinomas

Large cell carcinoma 97

Adenosquamous carcinoma

Adenosquamous carcinoma 100

Sarcomatoid carcinomas

Pleomorphic carcinoma 103

Pulmonary blastoma 106

Carcinosarcoma 109

Other epithelial tumours

NUT carcinoma of the lung (see Ch. 5)

Thoracic SMARCA4-deficient undifferentiated tumour 111

Salivary gland-type tumours

Pleomorphic adenoma 115

Adenoid cystic carcinoma 117

Epithelial-myoepithelial carcinoma 119

Mucoepidennoid carcinoma 121

Hyalinizing clear cell carcinoma 123

Myoepithelioma and myoepithelial carcinoma 125

Lung neuroendocrine neoplasms

Introduction 127

Precursor lesion

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 130

Neuroendocrine tumours

Carcinoid/neuroendocrine tumour 133

Neuroendocrine carcinomas

Small cell lung carcinoma 139

Large cell neuroendocrine carcinoma 144

Tumours of ectopic tissues

Melanoma 150

Meningioma 152

Mesenchymal tumours specific to the lung

Pulmonary hamartoma 154

Pulmonary chondroma 156

Diffuse pulmonary lymphangiomatosis 158

Pleuropulmonary blastoma 160

Pulmonary artery intimal sarcoma 164

Congenital peribronchial myofibroblastic tumour 166

Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion 168

PEComatous tumours

Lymphangioleiomyomatosis 170

PEComa 172

Haematolymphoid tumours

Introduction 174

MALT lymphoma 175

Diffuse large B-cell lymphoma 178

Lymphomatoid granulomatosis 181

Intravascular large B-cell lymphoma 184

Pulmonary Langerhans cell histiocytosis 186

Erdheim-Chester disease 189

2 Tumours of the pleura and pericardium 193

Introduction 194

Mesothelial tumours

Benign and preinvasive mesothelial tumours

Adenomatoid tumour 196

Well-differentiated papillary mesothelial tumour 198

Mesothelioma in situ 200

Mesothelioma

Localized mesothelioma 202

Diffuse mesothelioma 204

Haematolymphoid tumours

Introduction 220

Primary effusion lymphoma 221

Diffuse large B-cell lymphoma associated with chronic inflammation 224

3 Tumours of the heart 227

Introduction 228

Benign tumours

Papillary fibroelastoma 230

Cardiac myxoma 233

Cardiac fibroma 237

Cardiac rhabdomyoma 239

Adult cellular rhabdomyoma 241

Cardiac lipoma and lipomatous hypertrophy of the atrial septum 243

Lipomatous hamartoma of the atrioventricular valve 245

Hamartoma of mature cardiac myocytes 247

Mesenchymal cardiac hamartoma 249

Cardiac haemangiomas 251

Conduction system hamartoma 253

Cystic tumour of the atrioventricular node 256

Malignant tumours

Cardiac angiosarcoma 258

Cardiac leiomyosarcoma 260

Cardiac undifferentiated pleomorphic sarcoma 262

Other sarcomas that may involve the heart 265

Haematolymphoid tumours

Introduction 266

Cardiac diffuse large B-cell lymphoma 267

Cardiac fibrin-associated diffuse large B-cell lymphoma 269

4 Mesenchymal tumours of the thorax 273

Introduction 274

Mesenchymal tumours

Adipocytic tumours

Lipoma 276

Thymolipoma 278

Liposarcoma 280

Fibroblastic and myofibroblastic tumours

Desmoid fibromatosis 282

Solitary fibrous tumour 284

Calcifying fibrous tumour 286

Inflammatory myofibroblastic tumour 288

Myxofibrosarcoma 290

Vascular tumours

Haemangioma 292

Lymphangioma 294

Epithelioid haemangioendothelioma 296

Angiosarcoma 299

Skeletal muscle tumours

Rhabdomyosarcoma 301

Peripheral nerve sheath and neural tumours

Paraganglioma 303

Granular cell tumour 305

Schwannoma 307

Malignant peripheral nerve sheath tumour 309

Peripheral neuroblasts tumours 311

Tumours of uncertain differentiation

Synovial sarcoma 314

Undifferentiated small round cell sarcomas 316

5 Tumours of the thymus 319

Epithelial tumours

Thymoma

Introduction 320

Type A thymoma (including atypical subtype) 326

Type AB thymoma 329

Type B1 thymoma 332

Type B2 thymoma 336

Type B3 thymoma 340

Micronodular thymoma with lymphoid stroma 345

Metaplastic thymoma 347

Lipofibroadenoma 349

Thymic carcinoma

Introduction 351

Squamous cell carcinoma 354

Basaloid carcinoma 359

Lymphoepithelial carcinoma 361

NUT carcinoma of the thorax 364

Clear cell carcinoma 368

Low-grade papillary adenocarcinoma 370

Mucoepidermoid carcinoma 372

Thymic carcinoma with adenoid cystic carcinoma-like features 375

Enteric-type adenocarcinoma 377

Adenocarcinoma NOS 379

Adenosquamous carcinoma 381

Sarcomatoid carcinoma 383

Undifferentiated carcinoma 386

Thymic carcinoma NOS 388

Thymic neuroendocrine neoplasms

Introduction

Neuroendocrine tumours 389

Carcinoid/neuroendocrine tumour 391

Neuroendocrine carcinomas

Small cell carcinoma 395

Large cell neuroendocrine carcinoma 397

6 Germ cell tumours of the mediastinum 399

Introduction 400

Seminoma 402

Embryonal carcinoma 405

Yolk sac tumour 407

Choriocarcinoma 412

Teratoma 414

Mixed germ cell tumours 417

Germ cell tumours with somatic-type solid malignancy 419

Germ cell tumours with associated haematological malignancy 422

7 Haematolymphoid tumours of the mediastinum 425

Introduction 426

Primary mediastinal large B-cell lymphoma 427

MALT lymphoma 430

T-lymphoblastic leukaemia/lymphoma 432

Classic Hodgkin lymphoma 435

Mediastinal grey zone lymphoma 438

Follicular dendritic cell sarcoma 441

Myeloid sarcoma 443

8 Ectopic tumours of thyroid and parathyroid origin 445

Ectopic thyroid tumours 446

Ectopic parathyroid tumours 448

9 Metastases 451

Metastasis to the lung 452

Metastasis to the pleura 459

Metastasis to the thymus and mediastinal lymph nodes 463

Metastasis to the heart and pericardium 467

10 Genetic tumour syndromes involving the thorax 471

Introduction 472

Li-Fraumeni syndrome 474

BAP1 tumour predisposition syndrome 476

Carney complex 478

Contributors 481

Declaration of interests 488

IARC/WHO Committee for ICD-O 490

Sources 491

References 499

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